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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IKBKB All Species: 27.88
Human Site: Y294 Identified Species: 61.33
UniProt: O14920 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14920 NP_001547.1 756 86564 Y294 Q R G T D P T Y G P N G C F K
Chimpanzee Pan troglodytes XP_528121 757 86974 Y294 Q R G T D P T Y G P N G C F K
Rhesus Macaque Macaca mulatta XP_001096913 756 86591 Y294 Q R G T D P K Y G P N G C F K
Dog Lupus familis XP_539954 755 86445 Y294 Q R G T D P V Y G P N G C F K
Cat Felis silvestris
Mouse Mus musculus O88351 757 86672 Y294 Q R G T D P Q Y G P N G C F R
Rat Rattus norvegicus Q9QY78 757 86848 Y294 Q R G V D P Q Y G P N G C F R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509921 757 87360 Y294 Q R G T D H I Y G P N G C F K
Chicken Gallus gallus Q5ZJB4 759 86125 T309 G G G L D P E T N S P K C F L
Frog Xenopus laevis Q6GM53 743 85134 C293 Q R G G G I D C G R P R C F M
Zebra Danio Brachydanio rerio Q4G3H4 758 87129 S296 G L G L N T D S K Q P Q C F V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VEZ5 751 86354 N336 E R G Q L A A N N V P V V F A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.4 99.7 94.9 N.A. 91.8 91.2 N.A. 88.5 49.2 50.4 51.5 N.A. 25 N.A. N.A. N.A.
Protein Similarity: 100 98.4 99.7 97 N.A. 95.5 95.3 N.A. 92.7 67.8 68.3 67.9 N.A. 42.8 N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 93.3 N.A. 86.6 80 N.A. 86.6 33.3 40 20 N.A. 20 N.A. N.A. N.A.
P-Site Similarity: 100 100 93.3 93.3 N.A. 93.3 86.6 N.A. 86.6 33.3 40 26.6 N.A. 26.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 10 10 0 0 0 0 0 0 0 10 % A
% Cys: 0 0 0 0 0 0 0 10 0 0 0 0 91 0 0 % C
% Asp: 0 0 0 0 73 0 19 0 0 0 0 0 0 0 0 % D
% Glu: 10 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 % F
% Gly: 19 10 100 10 10 0 0 0 73 0 0 64 0 0 0 % G
% His: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 10 10 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 10 0 10 0 0 10 0 0 46 % K
% Leu: 0 10 0 19 10 0 0 0 0 0 0 0 0 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % M
% Asn: 0 0 0 0 10 0 0 10 19 0 64 0 0 0 0 % N
% Pro: 0 0 0 0 0 64 0 0 0 64 37 0 0 0 0 % P
% Gln: 73 0 0 10 0 0 19 0 0 10 0 10 0 0 0 % Q
% Arg: 0 82 0 0 0 0 0 0 0 10 0 10 0 0 19 % R
% Ser: 0 0 0 0 0 0 0 10 0 10 0 0 0 0 0 % S
% Thr: 0 0 0 55 0 10 19 10 0 0 0 0 0 0 0 % T
% Val: 0 0 0 10 0 0 10 0 0 10 0 10 10 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 64 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _